Developing first-in-class cardiovascular biopharmaceuticals that target natural repair pathways.


Rahul Aras, President and CEO

Rahul Aras, Ph.D.
(Co-Founder, President and Chief Executive Officer)

is the founding CEO for Juventas Therapeutics. Dr. Aras has led the Company since its inception in 2007 and has leveraged his scientific research and business experience to lead Juventas towards commercialization of its innovative therapies. Dr. Aras has successfully transitioned Juventas’ technologies from the laboratory into mid-stage clinical trials. Prior to leading Juventas, Dr. Aras was the Director of Life Science Commercialization at Cleveland Clinic Innovations where he managed commercialization of all biotechnology and pharmaceutical related technologies developed at Cleveland Clinic. Dr. Aras has held research positions at Vanderbilt University Medical Center and Massachusetts General Hospital and has published articles in several leading scientific journals. He received a B.S. from Tufts University and a Ph.D. in biomedical research from New York University.

Mark Penn

Marc Penn, M.D., Ph.D.
(Co-Founder, Chief Medical Officer)
is the Director of Research at the Summa Cardiovascular Institute in Akron, Ohio and Professor of Medicine and Integrative Medical Sciences at Northeast Ohio Medical University where he leads the Skirball Laboratory for Cardiovascular Cellular Therapeutics. Dr. Penn was a staff cardiologist at the Cleveland Clinic from 2000 – 2011 where he served as the Director of the Coronary Intensive Care Unit, Director of the Experimental Animal Laboratory, Director of the Bakken Heart-Brain Institute, and the first Director of the Center for Cardiovascular Cell Therapy. He is a serial entrepreneur listed on more than 50 patents and patent applications and has contributed to the formation of multiple companies in the device, diagnostic and therapeutic spaces. Dr. Penn completed his undergraduate and postgraduate work at Case Western Reserve University completing a Ph.D. in Biomedical Engineering in 1989 and Doctor of Medicine in 1994.

Joe Pastore

Joseph Pastore, Ph.D.
(Senior Vice President, Clinical Product Development)
oversees manufacturing, preclinical, and clinical development. He has led the team that has translated Juventas’ lead product, JVS-100, from concept through Phase II trials. He is responsible for development and implementation of clinical/regulatory strategy, internal staffing and outsourcing of clinical operations, and leading interactions with the FDA which includes the approval of multiple Investigational New Drug (IND) submissions. Previous to Juventas, he worked with Guidant Corporation (acquired by Boston Scientific) where he was responsible for translating novel cardiac therapies from concept to clinic. He managed pre-clinical, first-in-man, and Phase II clinical trials, and worked cross-functionally with business development, marketing, reimbursement, and regulatory teams to build and execute development strategies for early stage products. He received his Ph.D. in Biomedical Engineering from Case Western Reserve University.