Developing first-in-class cardiovascular biopharmaceuticals that target natural repair pathways.

Scientific Publications

SDF-1 Research

Changes in ventricular remodeling and clinical status during the year following a single administration of stromal cell-derived factor-1 non-viral gene therapy in chronic ischaemic heart failure patients: the STOP-HF randomized Phase II trial.
Chung ES, Miller L, Patel AN, Anderson RD, Mendelsohn FO, Traverse J,
Silver KH, Shin J, Ewald G, Farr MJ, Anwaruddin S, Plat F, Fisher SJ,
AuWerter AT, Pastore JM, Aras R, Penn MS
European Heart Journal. 2015 Jun 7.
PMID: 26056125

An open-label dose escalation study to evaluate the safety of administration of nonviral stromal cell-derived factor-1 plasmid to treat symptomatic ischemic heart failure.
Penn MS, Mendelsohn FO, Schaer GL, Sherman W, Farr M, Pastore J, Rouy D, Clemens R, Aras R, Losordo DW.
Circulation Research. 2013 Mar 1;112(5):816-25.
PMID: 23429605

SDF-1 in myocardial repair.
Penn MS, Pastore J, Miller T, Aras R.
Gene Therapy. 2012 Jun;19(6):583-7.
PMID: 22673496

Myocardial CXCR4 Expression Is Required for Mesenchymal Stem Cell Mediated Repair Following Acute Myocardial Infarction.
Feng Dong, MD, PhD; James Harvey, MD; Amanda Finan, BS; Kristal Weber, BS; Udit Agarwal, MD, PhD; Marc S. Penn, MD, PhD
Circulation. 2012; 126: 314-324
PMID: 22685115

Plasmid-based transient human stromal cell-derived factor-1 gene transfer improves cardiac function in chronic heart failure.
Sundararaman S, Miller TJ, Pastore JM, Kiedrowski M, Aras R, Penn MS.
Gene Therapy. 2011 Sep;18(9):867-73.
PMID: 21472007

Continuous delivery of stromal cell-derived factor-1 from alginate scaffolds accelerates wound healing.
Rabbany SY1, Pastore J, Yamamoto M, Miller T, Rafii S, Aras R, Penn M.
Cell Transplant. 2010;19(4):399-408.
PMID: 19995484

Continuous delivery of stromal cell-derived factor-1 from alginate scaffolds accelerates wound healing.
Rabbany SY, Pastore J, Yamamoto M, Miller T, Rafii S, Aras R, Penn M.
Cell Transplant. 2010;19(4):399-408.
PMID: 19995484

Importance of the SDF-1:CXCR4 axis in myocardial repair.
Penn MS.
Circ Res. 2009 May 22;104(10):1133-5.
PMID: 19461103

Role of stem cell homing in myocardial regeneration.
Penn MS, Zhang M, Deglurkar I, Topol EJ.
Int J Cardiol. 2004 Jun;95 Suppl 1:S23-5.
PMID: 15336840

Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy.
Askari AT, Unzek S, Popovic ZB, Goldman CK, Forudi F, Kiedrowski M, Rovner A, Ellis SG, Thomas JD, DiCorleto PE, Topol EJ, Penn MS.
Lancet. 2003 Aug 30;362(9385):697-703.
PMID: 12957092

 

Poster Presentations

“A Phase IIa Randomized, Double-Blind, Placebo Controlled Study to Evaluate Plasmid Stromal Cell Derived Factor-1 for Treatment of Critical Limb Ischemia-The Stop-CLI Trial” poster presented at the American Society of Gene and Cell Therapy meeting, 2015

“Dermal SDF-1 over-expression immediately following surgical closure minimizes scar formation” poster presented at the American College of Surgeons meeting, 2014

“A Phase II, Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Safety and Efficacy of an Endomyocardial Injection of hSDF-1 Plasmid to Ischemic Heart Failure Patients, the STOP-HF Trial” poster presented at the European Society of Cardiology Congress, 2014

“Coronary Sinus Delivery of SDF-1 Plasmid for the Treatment of Heart Failure” poster presented at the American Society of Gene & Cell Therapy, 2014

“SDF-1 Plasmid Treatment for Patients with Heart Failure (STOP-HF)” poster presented at the Heart Failure Society of America Meeting, 2013

“An Open Label Dose Escalation Study to Evaluate the Safety of Administration of Non-viral SDF-1 Plasmid to Treat Symptomatic Ischemic Heart Failure” poster presented at the Heart Failure Society of America Meeting, 2012

“Intramuscular Gene Transfer of Stromal Cell-Derived Factor-1 using plasmid JVS-100 Induces Therapeutic Angiogenesis in a Rabbit Model of Peripheral Vascular Disease” poster presented at New Horizons, 2011

“Intra-myocardial administration of JVS-100 promotes cardiac benefit and improves angiogenesis in a porcine model of heart failure” poster presented at the American Society of Gene & Cell Therapy 2010

“Intramuscular delivery of JVS-100 enhances angiogenesis in rabbits with hind limb ischemia” poster presented at the American Society of Gene & Cell Therapy, 2010